Chi Lab - Publications

Hop2-Mnd1 functions as a DNA sequence fidelity switch in Dmc1-mediated DNA recombination

Peng, J.C., Chang, H.Y., Sun, Y.L., Prentiss, L., Chi, P.*

Nat Commun

pubmed

article

Protocol for detecting homologous recombination activity in cancer cells by adenovirus-based functional assay

Huang, S.H., Lee, C.Y., Chi, P.*

STAR Protoc

pubmed

article

Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from Arabidopsis thaliana

Chen, H.W.^†, Yeh, H.Y.^†, Chang, C.C., Kuo, W.C., Lin, S.W., Vrielynck, N., Grelon, M., Chan, N.L.*, Chi, P.* (^†denotes equal contribution)

Nucleic Acids Res

pubmed

article

Mei5–Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA

Wei, C.D.^†, Chang, H.Y.^†, Lu, C.H., Chang, C.C., Furukohri, A., Mwanki, S., Shinohara, A., Chi, P.*, Li, H.W.* (^†denotes equal contribution)

Nucleic Acids Res

pubmed

article

CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection

Jaiswal, R.K., Lei, K.H., Chastain, M., Wang, Y., Shiva, O., Li, S., You, Z., Chi, P., Chai, W.*

Nat. Commun.

pubmed

article

An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time

Lee, C.Y., Cheng, W.F., Lin, P.H., Chen, Y.L., Huang, S.H., Lei, K.H., Chang, K.Y., Ko, M.Y., Chi, P.*

Cell Rep. Med.

pubmed

article

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases

Guh, C.L., Lei, K.H., Chen, Y.A., Jiang, Y.Z., Chang, H.Y., Liaw, H., Li, H.W., Yen, H.Y., Chi, P.*

Nucleic Acids Res.

pubmed

article

A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination

Luo, S.C., Yeh, M.C., Lien, Y.H., Yeh, H.Y., Siao, H.L., Tu, I.P., Chi, P., Ho, M.C.*

Nat. Commun.

pubmed

article

Flap endonuclease Rad27 cleaves the RNA of R-loop structures to suppress telomere recombination

Liu, C.C., Chan, H.R., Su, G.C., Hsieh, Y.Z., Lei, K.H., Kato, T., Yu, T.Y., Kao, Y.W., Cheng, T.H., Chi, P.*, Lin, J.J.*

Nucleic Acids Res.

pubmed

article

PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair

Ho, Y.C., Ku, C.S., Tsai, S.S., Shiu, J.L., Jiang, Y.Z., Miriam, H.E., Zhang, H.W., Chen, Y.T., Chiu, W.T., Chang, S.B., Shen, C.H., Myung, K., Chi, P., Liaw, H.*

PLoS Genet.

pubmed

article

Comparison of ATP-binding pockets and discovery of homologous recombination inhibitors

Blay, V., Gailiunaite, S., Lee, C.Y., Chang, H.Y., Hupp, T., Houston, D.R.*, Chi, P.

Bioorg. Med. Chem.

pubmed

article

Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Chen, W.T., Tseng, H.Y., Jiang, C.L., Lee, C.Y., Chi, P., Chen, L.Y., Lo, K.Y., Wang, I.C., Lin, F.J.*

J. Biomed. Sci.

pubmed

article

Crosstalk between CST and RPA regulates RAD51 activity during replication stress

Lei, K.H., Yang, H.L., Chang, H.Y., Yeh, H.Y., Nguyen, D.D., Lee, T.Y., Lyu, X., Chastain, M., Chai, W., Li, H.W.*, Chi, P.*

Nat. Commun.

pubmed

article

Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks

Hinman, A.W., Yeh, H.Y., Roelens, B., Yamaya, K., Woglar, A., Bourbon, H.G., Chi, P., Villeneuve, A.M.*

Proc. Natl. Acad. Sci. USA

pubmed

article

Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequences

Li, W.C., Lee, C.Y., Lan, W.H., Woo, T.T., Liu, H.C., Yeh, H.Y., Chang, H.Y., Chuang, Y.C., Chen, C.Y., Chuang, C.N., Chen, C.L., Hsueh, Y.P., Li, H.W.*, Chi, P.*, and Wang, T.F.*

Proc. Natl. Acad. Sci. USA

pubmed

article

Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures

Luo, S.C., Yeh, H.Y., Lan, W.H., Wu, Y.M., Yang, C.H., Chang, H.Y., Su, G.C., Lee, C.Y., Wu, W.J., Li, H.W., Ho, M.C.*., Chi, P.*, and Tsai, M.D.*

Nat. Commun.

pubmed

article

Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA

Lyu, X., Lei, K.H., Biak Sang, P., Shiva, O., Chastain, M., Chi, P.*, and Chai, W.*

EMBO J

pubmed

article

Microcephaly family protein MCPH1 stabilizes RAD51 filaments

Chang, H.Y., Lee, C.Y., Lu, C.H., Lee, W., Yang, H.L., Yeh, H.Y., Li, H.W.*, Chi, P.* (2020)

Nucleic Acids Res.

pubmed

article

Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinase

Lan, W.H., Lin, S.Y., Kao, C.Y., Chang, W.H., Yeh, H.Y., Chang, H.Y., Chi, P.*, Li, H.W.* (2020)

Proc. Natl. Acad. Sci. USA

pubmed

article

Promotion of homology-directed DNA repair by polyamines

Lee, C.Y., Su, G.C., Huang, W.Y., Ko, M.Y., Yeh, H.Y., Chang, G.D., Lin, S.J., Chi, P.* (2019)

Nat. Commun.

pubmed

article

Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Klein, H.L.*, Ang, K.K.H., Arkin, M.R., Beckwitt, E.C., Chang, Y.H., Fan, J., Kwon, Y., Morten, M.J., Mukherjee, S., Pambos, O.J., El Sayyed, H., Thrall, E.S., Vieira-da-Rocha, J.P., Wang, Q., Wang, S., Yeh, H.Y., Biteen, J.S., Chi, P., Heyer, W.D., Kapanidis, A.N., Loparo, J.J., Strick, T.R., Sung, P., Van Houten, B., Niu, H.*, Rothenberg, E*. (2019)

Microb. Cell

pubmed

article

Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation

Lu, C.H., Yeh, H.Y., Su, G.C., Ito, K., Kurokawa, Y., Iwasaki, H.*, Chi, P.*, Li, H.W.* (2018)

Proc. Natl. Acad. Sci. USA

pubmed

article

Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapy

Huang, W.Y., Lai, S.F., Chiu, H.Y., Chang, M., Plikus, M., Chan, C.C., Chen, Y.T., Tsao, P.N., Yang, T.L., Lee, H.S., Chi, P., Lin, S.J.* (2017)

Cancer Res.

pubmed

article

Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans

Yeh, H.Y., Lin, S.W., Wu, Y.C., Chan, N.L., Chi, P.* (2017)

Sci. Rep.

pubmed

article

Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer

Chao, A., Chang, T.C., Lapke, N., Jung, S.M., Chi, P., Chen, C.H., Yang, L.Y., Lin, C.T., Huang, H.J., Chou, H.H., Liou, J.D., Chen, S.J.*, Wang, T.H.*, Lai, C.H.* (2016)

Oncotarget

pubmed

article

Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination

Su, G.C., Yeh, H.Y., Lin, S.W., Chung, C.I., Huang, Y.S., Liu, Y.C., Lyu, P.C., Chi, P.* (2016)

Nucleic Acids Res.

pubmed

article

Functional relationship of ATP hydrolysis, presynaptic filament stability, and homologous DNA pairing activity of the human meiotic recombinase DMC1

Chang, H.Y., Liao, C.Y., Su G.C., Lin, S.W., Wang, H.W., Chi, P.* (2015)

J. Biol. Chem.

pubmed

article

Purification of recombinant nacre-associated mineralization protein AP7 fused with maltose-binding protein

Huang, Y.C., Chang, H.H., Mou, Y., Chi, P., Chan, J.C., Luo, S.C.* (2014)

Protein Expr. Purif.

pubmed

article

Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex

Su, G.C., Chung, C.I., Liao, C.Y., Lin, S.W., Tsai, C.T., Huang, T., Li, H.W., Chi, P.* (2014)

Nucleic Acids Res.

pubmed

article

Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing

Zhao, W., Saro, D., Hammel, M., Kwon, Y., Xu Y., Rambo, R.P., Williams, G.J., Chi, P., Lu, L., Pezza, R.J., Camerini-Otero, R.D., Tainer, J.A., Wang, H.W., Sung, P.* (2013)

Nucleic Acids Res.

pubmed

article

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

Wilson, M.A., Kwon, Y., Xu, Y., Chung, W.H., Chi, P., Niu, H., Mayle, R., Chen, X., Malkova, A., Sung, P.*, Ira, G.* (2013)

Nature

pubmed

article

Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1

Busygina, V., Gaines, W.A., Xu, Y., Kwon, Y., Williams, G.J., Lin, S.W., Chang, H.Y., Chi, P., Wang, H.W., Sung, P.* (2013)

DNA Repair (Amst)

pubmed

article

Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response

Chen, C.H., Chu, P.C., Lee, L., Lien, H.W., Lin, T.L., Fan, C.C., Chi, P., Huang, C.J., Chang, M.S.* (2012)

PLoS One

pubmed

article

Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex

Tsai, S.P., Su, G.C., Lin, S.W., Chung, C.I., Xue, X., Dunlop, M.H., Akamatsu, Y., Jasin, M., Sung, P., Chi, P.* (2012)

Nucleic Acids Res.

pubmed

article

Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors

Chi P., Kwon Y., Visnapuu M.L., Lam I., Santa Maria S.R., Zheng X., Epshtein A., Greene E.C., Sung P., Klein H.L.* (2011)

Nucleic Acids Res.

pubmed

article

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

Niu, H., Chung, W.H., Zhu, Z., Kwon, Y., Zhao, W., Chi, P., Prakash, R., Seong, C., Liu, D., Lu, L., Ira, G., Sung, P.* (2010)

Nature

pubmed

article

Functional interactions of meiotic recombination factors Rdh54 and Dmc1

Chi, P., Kwon, Y., Moses, D.N., Seong, C., Sehorn, M.G., Singh, A.K., Tsubouchi, H., Greene, E.C., Klein, H.L., Sung, P.* (2009)

DNA Repair (Amst)

pubmed

article

Structural transitions within human Rad51 nucleoprotein filaments

Robertson, R.B., Moses, D.N., Kwon, Y., Chan, P., Chi, P., Klein, H., Sung, P., Greene, E.C.* (2009)

Proc. Natl. Acad. Sci. USA

pubmed

article

Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments

Robertson, R.B., Moses, D.N., Kwon, Y., Chan, P., Zhao, W., Chi, P., Klein, H., Sung, P., Greene, E.C.* (2009)

J. Mol. Biol.

pubmed

article

ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54

Kwon, Y., Seong, C., Chi, P., Greene, E.C., Klein, H., Sung, P.* (2008)

J. Biol. Chem.

pubmed

article

Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52

Seong, C., Sehorn, M.G., Plate, I., Shi, I., Song, B., Chi, P., Mortensen, U., Sung, P., Krejci, L.* (2008)

J. Biol. Chem.

pubmed

article

A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops

Prasad, T.K., Robertson, R.B., Visnapuu, M.L., Chi, P., Sung, P., Greene, E.C.* (2007)

J. Mol. Biol.

pubmed

article

Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.

Chi, P., San Filippo, J., Sehorn, M.G., Petukhova, G.V., Sung, P.* (2007)

Genes Dev.

pubmed

article

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

Hu, Y., Raynard, S., Sehorn, M.G., Lu, X., Bussen, W., Zheng, L., Stark, J.M., Barnes, E.L., Chi, P., Janscak, P., Jasin, M., Vogel, H., Sung, P.*, Luo, G.* (2007)

Genes Dev.

pubmed

article

Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.

Kwon, Y., Chi, P., Roh, D.H., Klein, H., Sung, P.* (2007)

DNA Repair (Amst)

pubmed

article

Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

San Filippo, J., Chi, P., Sehorn, M.G., Etchin, J., Krejci, L., Sung, P.* (2006)

J. Biol. Chem.

pubmed

article

Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function

Chi, P., Van Komen, S., Sehorn, M.G., Sigurdsson, S., Sung, P.* (2006)

DNA Repair (Amst)

pubmed

article

Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA

Chi, P., Kwon, Y., Seong, C., Epshtein, A., Lam, I., Sung, P.*, Klein, H.L.* (2006)

J. Biol. Chem.

pubmed

article

Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54

Raschle, M., Van Komen, S., Chi, P., Ellenberger, T., Sung, P.* (2004)

J. Biol. Chem.

pubmed

article

Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein

Chi, W.J., Doong, S.L., Lin-Shiau, S.Y., Boone, C.W., Kelloff, G.J., Lin, J.K.* (1998)

Carcinogenesis

pubmed

article

Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from Arabidopsis thaliana

Chen, H.W.^†, Yeh, H.Y.^†, Chang, C.C., Kuo, W.C., Lin, S.W., Vrielynck, N., Grelon, M., Chan, N.L.*, Chi, P.* (2024) (^†denotes equal contribution)

Nucleic Acids Res.

pubmed

article

CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection

Jaiswal, R.K., Lei, K.H., Chastain, M., Wang, Y., Shiva, O., Li, S., You, Z., Chi, P., Chai, W.* (2023)

Nat. Commun.

pubmed

article

An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time

Lee, C.Y., Cheng, W.F., Lin, P.H., Chen, Y.L., Huang, S.H., Lei, K.H., Chang, K.Y., Ko, M.Y., Chi, P.* (2023)

Cell Rep. Med.

pubmed

article

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases

Guh, C.L., Lei, K.H., Chen, Y.A., Jiang, Y.Z., Chang, H.Y., Liaw, H., Li, H.W., Yen, H.Y., Chi, P.* (2023)

Nucleic Acids Res.

pubmed

article

A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination

Luo, S.C., Yeh, M.C., Lien, Y.H., Yeh, H.Y., Siao, H.L., Tu, I.P., Chi, P., Ho, M.C.* (2023)

Nat. Commun.

pubmed

article

Flap endonuclease Rad27 cleaves the RNA of R-loop structures to suppress telomere recombination

Liu, C.C., Chan, H.R., Su, G.C., Hsieh, Y.Z., Lei, K.H., Kato, T., Yu, T.Y., Kao, Y.W., Cheng, T.H., Chi, P.*, Lin, J.J.* (2023)

Nucleic Acids Res.

pubmed

article

PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair

Ho, Y.C., Ku, C.S., Tsai, S.S., Shiu, J.L., Jiang, Y.Z., Miriam, H.E., Zhang, H.W., Chen, Y.T., Chiu, W.T., Chang, S.B., Shen, C.H., Myung, K., Chi, P., Liaw, H.* (2022)

PLoS Genet.

pubmed

article

Comparison of ATP-binding pockets and discovery of homologous recombination inhibitors

Blay, V., Gailiunaite, S., Lee, C.Y., Chang, H.Y., Hupp, T., Houston, D.R.*, Chi, P. (2022)

Bioorg. Med. Chem.

pubmed

article

Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Chen, W.T., Tseng, H.Y., Jiang, C.L., Lee, C.Y., Chi, P., Chen, L.Y., Lo, K.Y., Wang, I.C., Lin, F.J.* (2021)

J. Biomed. Sci.

pubmed

article

Crosstalk between CST and RPA regulates RAD51 activity during replication stress

Lei, K.H., Yang, H.L., Chang, H.Y., Yeh, H.Y., Nguyen, D.D., Lee, T.Y., Lyu, X., Chastain, M., Chai, W., Li, H.W.*, Chi, P.* (2021)

Nat. Commun.

pubmed

article

Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks

Hinman, A.W., Yeh, H.Y., Roelens, B., Yamaya, K., Woglar, A., Bourbon, H.G., Chi, P., Villeneuve, A.M.* (2021)

Proc. Natl. Acad. Sci. USA

pubmed

article

Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequences

Li, W.C., Lee, C.Y., Lan, W.H., Woo, T.T., Liu, H.C., Yeh, H.Y., Chang, H.Y., Chuang, Y.C. Chen, C.Y., Chuang, C.N., Chen, C.L., Hsueh, Y.P., Li, H.W.*, Chi, P.*, Wang, T.F.* (2021)

Proc. Natl. Acad. Sci. USA

pubmed

article

Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures

Luo, S.C., Yeh, H.Y., Lan, W.H., Wu, Y.M., Yang, C.H., Chang, H.Y., Su, G.C., Lee, C.Y., Wu, W.J., Li, H.W., Ho, M.C.*., Chi, P.*, Tsai, M.D.* (2021)

Nat. Commun.

pubmed

article

Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA

Lyu, X., Lei, K.H., Biak Sang, P., Shiva, O., Chastain, M., Chi, P.*, Chai, W.* (2021)

EMBO J

pubmed

article

Microcephaly family protein MCPH1 stabilizes RAD51 filaments

Chang, H.Y., Lee, C.Y., Lu, C.H., Lee, W., Yang, H.L., Yeh, H.Y., Li, H.W.*, Chi, P.* (2020)

Nucleic Acids Res.

pubmed

article

Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinase

Lan, W.H., Lin, S.Y., Kao, C.Y., Chang, W.H., Yeh, H.Y., Chang, H.Y., Chi, P.*, Li, H.W.* (2020)

Proc. Natl. Acad. Sci. USA

pubmed

article

Promotion of homology-directed DNA repair by polyamines

Lee, C.Y., Su, G.C., Huang, W.Y., Ko, M.Y., Yeh, H.Y., Chang, G.D., Lin, S.J., Chi P*. (2019)

Nat. Commun.

pubmed

article

Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Klein, H.L., Ang, K.K.H., Arkin, M.R., Beckwitt, E.C., Chang, Y.H., Fan, J., Kwon, Y., Morten, M.J., Mukherjee, S., Pambos, O.J., El Sayyed, H., Thrall, E.S., Vieira-da-Rocha, J.P., Wang, Q., Wang, S., Yeh, H.Y., Biteen, J.S., Chi, P., Heyer, W.D., Kapanidis, A.N., Loparo, J.J., Strick, T.R., Sung, P., Van Houten, B., Niu, H., Rothenberg, E. (2019)

Microb. Cell

pubmed

article

Swi5-Sfr1 stimulates Rad51 eecombinase filament assembly by modulating Rad51 dissociation

Lu, C.H., Yeh, H.Y., Su, G.C., Ito, K., Kurokawa, Y., Iwasaki, H.*, Chi, P.*, Li, H.W.* (2018)

Proc. Natl. Acad. Sci. USA

pubmed

article

Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapy

Huang, W.Y., Lai, S.F., Chiu, H.Y., Chang, M., Plikus, M., Chan, C.C., Chen, Y.T., Tsao, P.N., Yang, T.L., Lee, H.S., Chi, P., Lin, S.J.* (2017)

Cancer Res.

pubmed

article

Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans

Yeh, H.Y., Lin, S.W., Wu, Y.C., Chan, N.L., and Chi, P.* (2017)

Sci. Rep.

pubmed

article

Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer

Chao, A., Chang, T.C., Lapke, N., Jung, S.M., Chi, P., Chen, C.H., Yang, L.Y., Lin, C.T., Huang, H.J., Chou, H.H., Liou, J.D., Chen, S.J.*, Wang, T.H.*, and Lai, C.H.* (2016)

Oncotarget

pubmed

article

Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination

Su, G.C., Yeh, H.Y., Lin, S.W., Chung, C.I., Huang, Y.S., Liu, Y.C., Lyu, P.C., Chi, P.* (2016)

Nucleic Acids Res.

pubmed

article

Functional relationship of ATP hydrolysis, presynaptic filament stability, and homologous DNA pairing activity of the human meiotic recombinase DMC1

Chang, H.Y., Liao, C.Y., Su, G.C., Lin, S.W., Wang, H.W., Chi, P.* (2015)

J. Biol. Chem.

pubmed

article

Purification of recombinant nacre-associated mineralization protein AP7 fused with maltose-binding protein

Huang, Y.C., Chang, H.H., Mou, Y., Chi, P., Chan, J.C., Luo, S.C.* (2014)

Protein Exp. Purif.

pubmed

article

Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex

Su, G.C., Chung, C.I., Liao, C.Y., Lin, S.W., Tsai, C.T., Huang, T., Li, H.W., Chi, P.* (2014)

Nucleic Acids Res.

pubmed

article

Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing

Zhao, W., Saro, D., Hammel, M., Kwon, Y., Xu Y., Rambo, R.P., Williams, G.J., Chi, P., Lu, L., Pezza, R.J., Camerini-Otero, R.D., Tainer, J.A., Wang, H.W., Sung, P.* (2014)

Nucleic Acids Res.

pubmed

article

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

Wilson, M.A., Kwon, Y., Xu, Y., Chung, W.H., Chi, P., Niu, H., Mayle, R., Chen, X., Malkova, A., Sung, P.*, Ira, G.* (2013)

Nature

pubmed

article

Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1

Busygina, V., Gaines, W.A., Xu, Y., Kwon, Y., Williams, G.J., Lin, S.W., Chang, H.Y., Chi, P., Wang, H.W., Sung, P.* (2013)

DNA Repair (Amst)

pubmed

article

Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response

Chen, C.H., Chu, P.C., Lee, L., Lien, H.W., Lin, T.L., Fan, C.C., Chi, P., Huang, C.J., Chang, M.S.* (2012)

PLoS One

pubmed

article

Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex

Tsai, S.P., Su, G.C., Lin, S.W., Chung, C.I., Xue, X., Dunlop, M.H., Akamatsu, Y., Jasin, M., Sung, P., Chi, P.* (2012)

Nucleic Acids Res.

pubmed

article

Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors

Chi, P., Kwon, Y., Visnapuu, M.L., Lam, I., Santa Maria, S.R., Zheng, X., Epshtein, A., Greene, E.C., Sung, P., Klein, H.L.* (2011)

Nucleic Acids Res.

pubmed

article

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

Niu, H., Chung, W.H., Zhu, Z., Kwon, Y., Zhao, W., Chi, P., Prakash, R., Seong, C., Liu, D., Lu, L., Ira, G., Sung, P.* (2010)

Nature

pubmed

article

Functional interactions of meiotic recombination factors Rdh54 and Dmc1

Chi, P., Kwon, Y., Moses, D.N., Seong, C., Sehorn, M.G., Singh, A.K., Tsubouchi, H., Greene, E.C., Klein, H.L., Sung, P.* (2009)

DNA Repair (Amst)

pubmed

article

Structural transitions within human Rad51 nucleoprotein filaments

Robertson, RB, Moses, DN, Kwon, Y, Chan, P, Chi, P, Klein, H, Sung, P, Greene, EC.* (2009)

J. Biomed. Sci.

pubmed

article

Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments

Robertson, R.B., Moses, D.N., Kwon, Y., Chan, P., Zhao, W., Chi, P., Klein, H., Sung, P., Greene, E.C. (2009)

Proc. Natl. Acad. Sci. USA

pubmed

article

ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54

Kwon, Y., Seong, C., Chi, P., Greene, E.C., Klein, H., Sung, P.* (2008)

J. Biol. Chem.

pubmed

article

Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52

Seong, C., Sehorn, M.G., Plate, I., Shi, I., Song, B., Chi, P., Mortensen, U., Sung, P., Krejci, L.* (2008)

J. Biol. Chem.

pubmed

article

A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops

Prasad, T.K., Robertson, R.B., Visnapuu, M.L., Chi, P., Sung, P., Greene, E.C.* (2007)

J. Mol. Biol.

pubmed

article

Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.

Chi, P., San Filippo, J., Sehorn, M.G., Petukhova, G.V., Sung, P.* (2007)

Genes Dev.

pubmed

article

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

Hu, Y., Raynard, S., Sehorn, M.G., Lu, X., Bussen, W., Zheng, L., Stark, J.M., Barnes, E.L., Chi, P., Janscak, P., Jasin, M., Vogel, H., Sung, P.*, Luo, G.* (2007)

Genes Dev.

pubmed

article

Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.

Kwon, Y., Chi, P., Roh, D.H., Klein, H., Sung, P.* (2007)

DNA Repair (Amst)

pubmed

article

Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

San Filippo, J., Chi, P., Sehorn, M.G., Etchin, J., Krejci, L., Sung, P.* (2006)

J. Biol. Chem.

pubmed

article

Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function

Chi, P., Van Komen, S., Sehorn, M.G., Sigurdsson, S., Sung, P.* (2006)

DNA Repair (Amst)

pubmed

article

Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA

Chi, P., Kwon, Y., Seong, C., Epshtein, A., Lam, I., Sung, P.*, Klein, H.L.* (2006)

J. Biol. Chem.

pubmed

article

Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54

Raschle, M., Van Komen, S., Chi, P., Ellenberger, T., Sung, P.* (2004)

J. Biol. Chem.

pubmed

article

Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein

Chi, W.J., Doong, S.L., Lin-Shiau, S.Y., Boone, C.W., Kelloff, G.J., Lin, J.K.* (1998)

Carcinogenesis

pubmed

article